The Hopkins Symptom Checklist–25 (HSCL-25) is a widely applied measure of depression and anxiety. The present study examines two of its short forms—the HSCL-5 and HSCL-10, which have been proposed by previous research—in a representative sample of the German general population. To this end, we conducted exploratory and confirmatory analysis on two subsamples ( n = 1,246 and n = 1,216). Our results suggest that, compared with the HSCL-25, both short forms represent economical ways of assessing depression and anxiety. Model fit was good and correlations with established measures demonstrate convergent validity. Both HSCL short forms are strongly invariant across sex, and we found evidence for partial strong invariance across age groups. Further analyses showed that differences in HSCL can be partially explained by sociodemographic variables. Finally, we report normative values for usage by researchers and clinicians. We recommend the HSCL-5 and HSCL-10 for clinical and research-oriented application.