AbstractThe process of destroying kidney stones using ultrasonic waves at certain frequencies has long been known in the medical field. The process of granular destruction using ultrasonic waves is very possible to produce a very fine grain size due to the large number of micro bubbles from the cavitation effect on the ultrasonic probe. The purpose of this research is to determine the effect of alcohol media in the destruction of calcium carbonate granules by ultrasonic waves to obtain carbonate calcium with nano-sized particles. The alcohol used in this study was 2-butanol, Ethylene glycol and n-propanol. The raw material of calcium carbonate was calcium carbonate precipitates originating from the Bayat region, Klaten Regency, Central Java, which was processed first by the carbonation method into calcium carbonate precipitates. The best result of experiments on the destruction of precipitated calcium carbonate by ultrasonic waves was the use of ethylene glycol media with ultrasonic time of 10 minutes and 30% amplitude. The result of the particle size analysis (PSA) at the best condition obtained with the average size of the granules of calcium carbonate precipitate was 72 nm.