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Elsevier, Journal of Psychosomatic Research, 3(77), p. 219-225, 2014

DOI: 10.1016/j.jpsychores.2014.06.014

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Cerebrospinal fluid markers of neuroinflammation in delirium: A role for interleukin-1β in delirium after hip fracture

Journal article published in 2014 by Eleanor Cape, Roanna J. Hall, Barbara C. van Munster, Annick de Vries, Sarah Em Howie, Andrew Pearson, Scott D. Middleton, Fiona Gillies, Ian R. Armstrong, Tim O. White, Colm Cunningham ORCID, Sophia E. de Rooij, Alasdair Mj MacLullich ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

•Exaggerated central inflammatory responses to stressors are implicated in delirium.•We examine cerebrospinal fluid (CSF) and serum cytokines in hip fracture patients.•We find increased CSF IL-1β in those about to develop delirium.•We find increased CSF interleukin-1 receptor antagonist in those with active delirium.