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Elsevier, Seminars in Cell and Developmental Biology, (31), p. 20-29, 2014

DOI: 10.1016/j.semcdb.2014.04.011

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The role of the cytoskeleton and molecular motors in endosomal dynamics

Journal article published in 2014 by Elizabeth Granger, Gavin McNee ORCID, Victoria Allan ORCID, Philip Woodman
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The endocytic pathway is essential for processes that define how cells interact with their environment, including receptor signalling, cell adhesion and migration, pathogen entry, membrane protein turnover and nutrient uptake. The spatial organisation of endocytic trafficking requires motor proteins that tether membranes or transport them along the actin and microtubule cytoskeletons. Microtubules, actin filaments and motor proteins also provide force to deform and assist in the scission of membranes, thereby facilitating endosomal sorting and the generation of transport intermediates.