Published in

Oxford University Press (OUP), Bioinformatics, 17(26), p. 2195-2197

DOI: 10.1093/bioinformatics/btq357

Links

Tools

Export citation

Search in Google Scholar

PriorsEditor: a tool for the creation and use of positional priors in motif discovery

Journal article published in 2010 by Kjetil Klepper, Finn Drabløs ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Summary: Computational methods designed to discover transcription factor binding sites in DNA sequences often have a tendency to make a lot of false predictions. One way to improve accuracy in motif discovery is to rely on positional priors to focus the search to parts of a sequence that are considered more likely to contain functional binding sites. We present here a program called PriorsEditor that can be used to create such positional priors tracks based on a combination of several features, including phylogenetic conservation, nucleosome occupancy, histone modifications, physical properties of the DNA helix and many more.