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Taylor and Francis Group, Journal of Biopharmaceutical Statistics, 3(24), p. 634-648

DOI: 10.1080/10543406.2014.888444

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A Nonparametric Multiple Imputation Approach for Data With Missing Covariate Values With Application to Colorectal Adenoma Data

Journal article published in 2014 by Chiu-Hsieh Hsu, Qi Long, Yisheng Li ORCID, Elizabeth Jacobs
This paper is available in a repository.
This paper is available in a repository.

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Abstract

A nearest neighbor-based multiple imputation approach is proposed to recover missing covariate information using the predictive covariates while estimating the association between the outcome and the covariates. To conduct the imputation, two working models are fitted to define an imputing set. This approach is expected to be robust to the underlying distribution of the data. We show in simulation and demonstrate on a colorectal data set that the proposed approach can improve efficiency and reduce bias in a situation with missing at random compared to the complete case analysis and the modified inverse probability weighted method.