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EMBO Press, EMBO Reports, 11(6), p. 1028-1034, 2005

DOI: 10.1038/sj.embor.7400557

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The chromosome cycle: coordinating replication and segregation

Journal article published in 2005 by J. Julian Blow ORCID, Tomoyuki U. Tanaka
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

During the cell-division cycle, chromosomal DNA must initially be precisely duplicated and then correctly segregated to daughter cells. The accuracy of these two events is maintained by two interlinked cycles: the replication licensing cycle, which ensures precise duplication of DNA, and the cohesion cycle, which ensures correct segregation. Here we provide a general overview of how these two systems are coordinated to maintain genetic stability during the cell cycle.