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Royal Society of Chemistry, RSC Advances, 34(9), p. 19325-19332, 2019

DOI: 10.1039/c9ra03251g

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Validated liquid chromatography tandem mass spectrometry for simultaneous quantification of foretinib and lapatinib, and application to metabolic stability investigation

Journal article published in 2019 by Mohammed M. Alanazi ORCID, Hamad M. Alkahtani ORCID, Abdulrahman A. Almehizia ORCID, Mohamed W. Attwa ORCID, Ahmed H. Bakheit, Hany W. Darwish
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Foretinib metabolic rate is decreased in combination with lapatinib. Lapatinib metabolic rate is greatly increased in combination with foretinib. Dose recalculation should be considered when foretinib and lapatinib are used in combination.