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Published in

Springer, Doklady Biochemistry and Biophysics, 1(486), p. 168-170, 2019

DOI: 10.1134/s1607672919030025

MAIK Nauka/Interperiodica, Доклады Академии Наук / Doklady Biological Sciences, 1(486), p. 114-117, 2019

DOI: 10.31857/s0869-56524861114-117

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Synuclein deficiency decreases the efficiency of dopamine uptake by synaptic vesicles

Journal article published in 2019 by N. N. Ninkina, T. V. Tarasova, K. D. Chaprov ORCID, V. V. Goloborshcheva, S. O. Bachurin, V. L. Buchman
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In the present study we analyzed uptake of radiolabeled dopamine by intact synaptosomes and purified synaptic vesicles isolated from the dorsal striatum of mice with constitutive inactivation of all three synuclein-coding genes and wild type mice. Synuclein deficiency substantially compromised the uptake of this neurotransmitter by synaptic vesicles whereas had no effect on synaptosomal dopamine uptake.