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Taylor and Francis Group, OncoImmunology, 10(2), p. e26247

DOI: 10.4161/onci.26247

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FOXP3-specific immunity

Journal article published in 2013 by Mads Hald Andersen
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Forkhead box P3 (FOXP3)-specific cytotoxic CD8(+) T cells are present among human peripheral blood mononuclear cells (PBMCs), especially in cancer patients. Such T lymphocytes are able not only to specifically recognize dendritic cells (DCs) that have been exposed to recombinant FOXP3 and regulatory T cells, but also to kill FOXP3(+) malignant T cells. The natural occurrence of FOXP3-specific cytotoxic T lymphocytes among human PBMCs suggests a general role for these cells in the complex network of immune regulation.