Published in
Royal Society of Chemistry, Chemical Science, 23(10), p. 5884-5892, 2019
DOI: 10.1039/c9sc01218d
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Potent and selective in vitro and in vivo antiproliferative effects of metal–organic trefoil knots
Journal article published in 2019 by
Farah Benyettou,
Thirumurugan Prakasam 
,
Anjana Ramdas Nair,
Ini-Isabee Witzel ,
Marwa Alhashimi,
Tina Skorjanc,
John-Carl Olsen,
Kirsten C. Sadler ,
Ali Trabolsi
,
Anjana Ramdas Nair,
Ini-Isabee Witzel ,
Marwa Alhashimi,
Tina Skorjanc,
John-Carl Olsen,
Kirsten C. Sadler ,
Ali Trabolsi
This paper is made freely available by the publisher.
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Abstract
A set of metal–organic trefoil knots (M-TKs) generated by metal-templated self-assembly of a simple pair of chelating ligands were well tolerated in vitro by non-cancer cells but were significantly more potent than cisplatin in both human cancer cells––including those resistant to cisplatin––and in zebrafish embryos.