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American Society for Microbiology, Journal of Virology, 3(85), p. 1391-1395, 2011

DOI: 10.1128/jvi.01459-10

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Nucleoprotein-RNA Orientation in the Measles Virus Nucleocapsid by Three-Dimensional Electron Microscopy

Journal article published in 2010 by Ambroise Desfosses, Gaël Goret, Leandro Farias Estrozi ORCID, Rob W. H. Ruigrok, Irina Gutsche
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Recombinant measles virus nucleoprotein-RNA (N-RNA) helices were analyzed by negative-stain electron microscopy. Three-dimensional reconstructions of trypsin-digested and intact nucleocapsids coupled to the docking of the atomic structure of the respiratory syncytial virus (RSV) N-RNA subunit into the electron microscopy density map support a model that places the RNA at the exterior of the helix and the disordered C-terminal domain toward the helix interior, and they suggest the position of the six nucleotides with respect to the measles N protomer.