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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 3(47), p. 1169-1172, 2003

DOI: 10.1128/aac.47.3.1169-1172.2003

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A New Sulfonamide Resistance Gene (sul3) in Escherichia coli Is Widespread in the Pig Population of Switzerland

Journal article published in 2003 by Vincent Perreten ORCID, Patrick Boerlin
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT A new gene, sul3 , which specifies a 263-amino-acid protein similar to a dihydropteroate synthase encoded by the 54-kb conjugative plasmid pVP440 from Escherichia coli was characterized. Expression of the cloned sul3 gene conferred resistance to sulfamethoxazole on E. coli . Two copies of the insertion element IS 15 Δ /26 flanked the region containing sul3 . The sul3 gene was detected in one-third of the sulfonamide-resistant pathogenic E. coli isolates from pigs in Switzerland.