nificant. Although the primary analysis of ECASS II showed a statistically nonsignificant result (40.3% of those treated and 36.6% of the control group made a complete recovery), a secondary analysis of "independent recovery" revealed a significant 8% difference despite patients being treated up to 6 hours after symptom onset. The NINDS data showed that the number needed to treat (NNT) to generate one additional independent recovery was 6. In comparison, treatment with ASA in the International Stroke Trial showed that 111 stroke patients would have to be treated with 300 mg of ASA to prevent one death or re- current stroke. 5