Published in
Oxford University Press, The American Journal of Clinical Nutrition, 6(97), p. 1217-1227, 2013
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DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women
Journal article published in 2013 by
Paula Dominguez-Salas,
Sophie E. Moore 
,
Darren Cole,
Kerry-Ann da Costa,
Sharon E. Cox,
Roger A. Dyer,
Anthony Jc Fulford,
Sheila M. Innis,
Robert A. Waterland,
Steven H. Zeisel,
Andrew M. Prentice,
Branwen J. Hennig
,
Darren Cole,
Kerry-Ann da Costa,
Sharon E. Cox,
Roger A. Dyer,
Anthony Jc Fulford,
Sheila M. Innis,
Robert A. Waterland,
Steven H. Zeisel,
Andrew M. Prentice,
Branwen J. Hennig
This paper is available in a repository.
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Abstract
Background: Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have been observed in offspring whose mothers were exposed to famine or who conceived in the Gambian rainy season.