Published in
Elsevier, Bioorganic and Medicinal Chemistry Letters, 18(20), p. 5552-5558
DOI: 10.1016/j.bmcl.2010.07.043
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Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach
Journal article published in 2010 by
Laetitia Mony,
Nicolas Triballeau,
Pierre Paoletti,
Francine C. Acher,
Hugues-Olivier Bertrand
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Abstract
We report the identification of a novel NR2B-selective NMDAR antagonist with an original scaffold, LSP10-0500. This compound was identified by a virtual high-throughput screening approach on the basis of a quantitative pharmacophore model of NR2B-specific NMDAR antagonists. A SAR study around LSP10-0500 is also described.