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Wiley, Angewandte Chemie International Edition, 4(48), p. 728-732, 2009

DOI: 10.1002/anie.200804107

Wiley, Angewandte Chemie, 4(121), p. 742-746, 2009

DOI: 10.1002/ange.200804107

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Ammosamides A and B Target Myosin**

Journal article published in 2009 by Chambers C. Hughes, John B. MacMillan, Susana P. Gaudêncio, William Fenical ORCID, James J. La Clair
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This paper is available in a repository.

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Abstract

The protein target of the ammosamides, cytotoxic natural products from a marine-derived actinomycete, has been elucidated. An immunoaffinity fluorescent tag was used to construct a fluorescent molecular probe (see structure). First, uptake and localization of the probe in cells was visualized with fluorescence microscopy. The probe was then used to co-immunoprecipitate proteins that bound to the ammosamide core. Myosin was thus identified as a target. (Figure Presented).