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Rockefeller University Press, Journal of Experimental Medicine, 3(200), p. 287-295, 2004

DOI: 10.1084/jem.20040370

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A Contribution of Mouse Dendritic Cell–Derived IL-2 for NK Cell Activation

Journal article published in 2004 by Francesca Granucci, Ivan Zanoni, Norman Pavelka, Serani L. H. van Dommelen, Slh Van Dommelen, Christopher E. Andoniou ORCID, Filippo Belardelli ORCID, Mariapia A. Degli Esposti, Degli Esposti, P. Castagnoli, Paola Ricciardi-Castagnoli
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Dendritic cells (DCs) play a predominant role in activation of natural killer (NK) cells that exert their functions against pathogen-infected and tumor cells. Here, we used a murine model to investigate the molecular mechanisms responsible for this process. Two soluble molecules produced by bacterially activated myeloid DCs are required for optimal priming of NK cells. Type I interferons (IFNs) promote the cytotoxic functions of NK cells. IL-2 is necessary both in vitro and in vivo for the efficient production of IFNgamma, which has an important antimetastatic and antibacterial function. These findings provide new information about the mechanisms that mediate DC-NK cell interactions and define a novel and fundamental role for IL-2 in innate immunity.