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Rockefeller University Press, Journal of Experimental Medicine, 3(199), p. 303-313, 2004

DOI: 10.1084/jem.20031562

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Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells

Journal article published in 2004 by Jochen Huehn, Kerstin Siegmund, Joachim C. U. Lehmann, Christiane Siewert, Uta Haubold, Markus Feuerer, Gudrun F. Debes ORCID, Joerg Lauber, Oliver Frey, Grzegorz K. Przybylski ORCID, Uwe Niesner, Maurus de la Rosa, Christian A. Schmidt, Rolf Bräuer, Jan Buer and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Regulatory T cells (Tregs) fulfill a central role in immune regulation. We reported previously that the integrin alphaEbeta7 discriminates distinct subsets of murine CD4+ regulatory T cells. Use of this marker has now helped to unravel a fundamental dichotomy among regulatory T cells. alphaE-CD25+ cells expressed L-selectin and CCR7, enabling recirculation through lymphoid tissues. In contrast, alphaE -positive subsets (CD25+ and CD25-) displayed an effector/memory phenotype expressing high levels of E/P-selectin-binding ligands, multiple adhesion molecules as well as receptors for inflammatory chemokines, allowing efficient migration into inflamed sites. Accordingly, alphaE -expressing cells were found to be the most potent suppressors of inflammatory processes in disease models such as antigen-induced arthritis.