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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 5(64), 2020

DOI: 10.1128/aac.01980-19

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Synthesis and biological activity of novel zinc-itraconazole complexes in protozoan parasites and Sporothrix spp.

Journal article published in 2020 by Jose Aleixo de Azevedo-França, Jose Aleixo de Azevedo França, Renato Granado, Sara Teixeira de Macedo Silva, Gabrielle dos Santos-Silva, Sandra Scapin, Luana P. Borba-Santos, Sonia Rozental ORCID, Wanderley de Souza, Érica S. Martins-Duarte, Emile Barrias, Juliany Cola Fernandes Rodrigues ORCID, Maribel Navarro
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The new complexes Zn(ITZ) 2 Cl 2 (1) and Zn(ITZ) 2 (OH) 2 (2) were synthetized by a reaction of itraconazole with their respective zinc salts under reflux. These Zn-ITZ complexes were characterized by elemental analyses, molar conductivity, mass spectrometry, 1 H and 13 C{ 1 H} nuclear magnetic resonance, and UV-vis and infrared spectroscopies. The antiparasitic and antifungal activity of Zn-ITZ complexes was evaluated against three protozoans of medical importance, namely, Leishmania amazonensis , Trypanosoma cruzi , and Toxoplasma gondii , and two fungi, namely, Sporothrix brasiliensis and Sporothrix schenckii .