Published in
Thieme Gruppe, Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, 10(30), p. 1178-1182, 2019
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Electrochemical C(sp3)–H Fluorination
Journal article published in 2019 by
Yusuke Takahira,
Miao Chen,
Yu Kawamata,
Pavel Mykhailiuk,
Hugh Nakamura,
Byron K. Peters 
,
Solomon H. Reisberg,
Chao Li,
Longrui Chen,
Tamaki Hoshikawa,
Tomoyuki Shibuguchi,
Phil S. Baran
,
Solomon H. Reisberg,
Chao Li,
Longrui Chen,
Tamaki Hoshikawa,
Tomoyuki Shibuguchi,
Phil S. Baran
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Abstract
A simple and robust method for electrochemical alkyl C–H fluorination is presented. Using a simple nitrate additive, a widely available fluorine source (Selectfluor), and carbon-based electrodes, a wide variety of activated and unactivated C–H bonds are converted into their C–F congeners. The scalability of the reaction is also demonstrated with a 100 gram preparation of fluorovaline.