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Cold Spring Harbor Laboratory Press, Genes & Development, 19(26), p. 2144-2153, 2012

DOI: 10.1101/gad.192294.112

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Age-associated inflammation inhibits epidermal stem cell function

Journal article published in 2012 by Jason Doles, Mekayla Storer, Luca Cozzuto ORCID, Guglielmo Roma, William M. Keyes
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Altered stem cell homeostasis is linked to organismal aging. However, the mechanisms involved remain poorly understood. Here we report novel alterations in hair follicle stem cells during skin aging, including increased numbers, decreased function, and an inability to tolerate stress. Performing high-throughput RNA sequencing on aging stem cells, cytokine arrays, and functional assays, we identify an age-associated imbalance in epidermal Jak–Stat signaling that inhibits stem cell function. Collectively, this study reveals a role for the aging epidermis in the disruption of cytokine and stem cell homeostasis, suggesting that stem cell decline during aging may be part of broader tumor-suppressive mechanisms.