As part of a building decommissioning and demolition program at Aberdeen Proving Ground, a detailed inspection of each target building is being conducted in order to characterize and describe the state of the building as it currently exists and to identify areas potentially contaminated with toxic or other hazardous substances. Room surfaces, drains and sumps, remaining equipment, and such associated exterior aboveground and underground appurtenances as tanks and pipelines are among the features, generically termed compartments, that may be potentially contaminated. Detailed drawings are being prepared for each building to illustrate the existing structure. This report presents the results of the inspection of Building E5375 in the Edgewood/Canal Creek area of Aberdeen Proving Ground. Nine potentially contaminated compartments were identified in this building and its vicinity.