Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 6(63), 2019
DOI: 10.1128/aac.02244-18
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Ceftriaxone and Cefotaxime Have Similar Effects on the Intestinal Microbiota in Human Volunteers Treated by Standard-Dose Regimens
Journal article published in 2019 by
Charles Burdet,
Nathalie Grall,
Morgane Linard 
,
Antoine Bridier-Nahmias ,
Michèle Benhayoun,
Khadija Bourabha,
Camille d’Humières,
Mélanie Magnan,
Olivier Clermont,
Olivier Tenaillon,
Sarah Tubiana,
Bruno Fantin,
Erick Denamur,
Loubna Alavoine,
Estelle Marcault
and other authors.
,
Antoine Bridier-Nahmias ,
Michèle Benhayoun,
Khadija Bourabha,
Camille d’Humières,
Mélanie Magnan,
Olivier Clermont,
Olivier Tenaillon,
Sarah Tubiana,
Bruno Fantin,
Erick Denamur,
Loubna Alavoine,
Estelle Marcault
and other authors.
This paper is made freely available by the publisher.
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Abstract
Ceftriaxone has a higher biliary elimination than cefotaxime (40% versus 10%), which may result in a more pronounced impact on the intestinal microbiota. We performed a monocenter, randomized open-label clinical trial in 22 healthy volunteers treated by intravenous ceftriaxone (1 g/24 h) or cefotaxime (1 g/8 h) for 3 days.