American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 6(63), 2019
DOI: 10.1128/aac.02244-18
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Ceftriaxone has a higher biliary elimination than cefotaxime (40% versus 10%), which may result in a more pronounced impact on the intestinal microbiota. We performed a monocenter, randomized open-label clinical trial in 22 healthy volunteers treated by intravenous ceftriaxone (1 g/24 h) or cefotaxime (1 g/8 h) for 3 days.