Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 6(63), 2019
DOI: 10.1128/aac.02174-18
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Low Antituberculosis Drug Concentrations in HIV-Tuberculosis-Coinfected Adults with Low Body Weight: Is It Time To Update Dosing Guidelines?
Journal article published in 2019 by
Christine Sekaggya-Wiltshire,
Maxwell Chirehwa,
Joseph Musaazi,
Amrei von Braun,
Allan Buzibye,
Daniel Muller,
Ursula Gutteck,
Ilaria Motta,
Andrea Calcagno,
Jan S. Fehr 
,
Andrew Kambugu,
Barbara Castelnuovo,
Mohammed Lamorde,
Paolo Denti
,
Andrew Kambugu,
Barbara Castelnuovo,
Mohammed Lamorde,
Paolo Denti
This paper is made freely available by the publisher.
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Abstract
Antituberculosis drugs display large pharmacokinetic variability, which may be influenced by several factors, including body size, genetic differences, and drug-drug interactions. We set out to determine these factors, quantify their effect, and determine the dose adjustments necessary for optimal drug concentrations.