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American Society for Microbiology, Infection and Immunity, 5(65), p. 1931-1935, 1997

DOI: 10.1128/iai.65.5.1931-1935.1997

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Production of tumor necrosis factor and nitric oxide by macrophages infected with live and dead mycobacteria and their suppression by an interleukin-10-secreting recombinant.

Journal article published in 1997 by B. G. Marshall, M. A. Chambers ORCID, A. Wangoo, R. J. Shaw, D. B. Young
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This paper is available in a repository.

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Abstract

We have analyzed mycobacterium-induced cytokine secretion in the J774A.1 macrophage-like cell line. Tumor necrosis factor alpha (TNF-alpha) was preferentially induced by live organisms, both slow and rapid growing. Expression of interleukin-10 by a recombinant strain of Mycobacterium smegmatis caused reduced production of TNF-alpha and nitric oxide during the early stages of infection.