Published in

American Society for Cell Biology, Molecular Biology of the Cell, 1(26), p. 134-150

DOI: 10.1091/mbc.e14-07-1193

Links

Tools

Export citation

Search in Google Scholar

Plasma membrane aminoglycerolipid flippase function is required for signaling competence in the yeast mating pheromone response pathway

Journal article published in 2015 by Elodie Sartorel, Evelyne Barrey, Rebecca K. Lau ORCID, Jeremy Thorner
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Red circle
Preprint: archiving forbidden
Green circle
Postprint: archiving allowed
Upload
Orange circle
Published version: archiving restricted
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Flippases that catalyze interleaflet lipid transfer, as well as the stimulatory protein kinase Fpk1, localize to the shmoo tip. Although viable and near-normal morphologically, cells lacking these flippases fail to respond to pheromone due to derangements in PtdIns(4,5)P2 localization, with ensuing effects on the level and/or function of MAPK scaffold protein Ste5.