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American Society for Microbiology, Journal of Clinical Microbiology, 4(41), p. 1760-1762, 2003

DOI: 10.1128/jcm.41.4.1760-1762.2003

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Drug-Associated Resistance Mutations in Plasma and Peripheral Blood Mononuclear Cells of Human Immunodeficiency Virus Type 1-Infected Patients for Whom Highly Active Antiretroviral Therapy Is Failing

Journal article published in 2003 by Loredana Sarmati, Emanuele Nicastri, Gabriella d'Ettorre ORCID, Ilaria Uccella, G. D'Ettorre, Saverio G. Parisi, Lucia Palmisano, Clementina Galluzzo, Ercole Concia, Vincenzo Vullo, Stefano Vella, Massimo Andreoni
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT In 32 patients for whom highly active antiretroviral therapy was failing, a good agreement between drug resistance-associated mutations in plasma and peripheral blood mononuclear cells (PBMCs) was found ( k = 0.85). The mutations with the lowest agreement were 20R, 63P, and 84V in the protease gene and 184V in the reverse transcriptase gene. In eight patients, primary drug resistance mutations were detected only in PBMCs.