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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 8(50), p. 2883-2885, 2006

DOI: 10.1128/aac.00177-06

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In Vitro Interactions between Piperaquine, Dihydroartemisinin, and Other Conventional and Novel Antimalarial Drugs

Journal article published in 2006 by Timothy M. E. Davis ORCID, Juliana Hamzah, Kenneth F. Ilett, Harin A. Karunajeewa, John C. Reeder, Kevin T. Batty, Sara Hackett ORCID, P. Hugh R. Barrett, P. Hugh R. Barrett
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT In an in vitro assessment of antimalarial combinations, dihydroartemisinin (DHA) showed no interaction or was mildly antagonistic when combined with piperaquine, pyronaridine, or naphthoquine. Interactions between 4-aminoquinolines and related drugs were also indifferent/antagonistic. The clinical significance of mildly antagonistic DHA combinations is uncertain but may become important if parasite drug sensitivity declines.