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Oxford University Press (OUP), Bioinformatics, 22(26), p. 2849-2855

DOI: 10.1093/bioinformatics/btq553

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A statistical framework for Illumina DNA methylation arrays

Journal article published in 2010 by Pei Fen Kuan, Sijian Wang, Xin Zhou ORCID, Haitao Chu ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Motivation: The Illumina BeadArray is a popular platform for profiling DNA methylation, an important epigenetic event associated with gene silencing and chromosomal instability. However, current approaches rely on an arbitrary detection P-value cutoff for excluding probes and samples from subsequent analysis as a quality control step, which results in missing observations and information loss. It is desirable to have an approach that incorporates the whole data, but accounts for the different quality of individual observations.