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Public Library of Science, PLoS ONE, 8(5), p. e12093, 2010

DOI: 10.1371/journal.pone.0012093

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ADAM10 Releases a Soluble Form of the GPNMB/Osteoactivin Extracellular Domain with Angiogenic Properties

Journal article published in 2010 by April A. N. Rose ORCID, Matthew G. Annis, Zhifeng Dong, Francois Pepin, Michael Hallett, Morag Park, Peter M. Siegel
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Glycoprotein non-metastatic melanoma protein B (GPNMB) is a type I transmembrane protein that is also known as Osteoactivin (OA), Dendritic Cell–Heparin Integrin Ligand (DC-HIL) or Hematopoietic Growth Factor Inducible Neurokinin-1 type (HGFIN). GPNMB/OA is expressed in a wide array of normal tissue types including: the bone, hematopoietic system and the skin. Within the bone, GPNMB/OA has been shown to promote the differentiation of both osteoclasts and osteoblasts. GPNMB/OA is also readily detectable in immune cells, such as macrophages and dendritic cells, and has been shown to functionally impair T-cell activation. Within the skin, GPNMB/OA has been proposed to be expressed specifically in melanocytes, while others suggest a broader pattern of expression that includes keratinocytes, melanocytes and Langerhans cells.