The aim of this study was to determine the levels of leptin (Lep) and adiponectin (AdipoQ) in patients with gout and its relationship with joint inflammatory data and/or with metabolic syndrome (MetS) variables, during 1 year follow-up. Forty-one patients (40 males) with gout diagnosis, attending for the first time to a rheumatology department, were included. Evaluations were performed baseline, at 6 and 12 months. Variables included the following: demographic, clinical and laboratory data related to gout and associated diseases. Lep and AdipoQ determinations by the ELISA method were performed in frozen serum from each visit. The pharmacological and no-pharmacological treatment for gout and associated diseases was individualized for each patient according to published guidelines. Statistical analysis included Mann–Whitney U test, Fisher test, x 2 , ANOVA, Cochran Q, Pearson and Spearman correlation tests, as well as linear regression. In the baseline evaluation, 29.2% had MetS (hypertriglyceridemia 66%, hypertension 44% and obesity 37%); patients with MetS had higher C reactive protein (CRP) levels [34.1 AE 28.6 vs. 12.2 AE 11.2 mg/dL, P ¼ 0.033]. Although not significant, also had higher Lep and lower AdipoQ levels (3.2 AE 3.0 vs. 1.9 AE 1.2 ng/mL, P ¼ 0.142 and 40.5 AE 26.8 vs. 38.0 AE 24.9 ng/mL, P ¼ 0.877, respectively). During follow up , our patients had significant improvement in serum uric acid (sUA) levels and variables evaluating pain and joint swelling (P 0.05). Metabolic abnormalities tended to persist or even worsen during the monitoring period: significant increase in total cholesterol (P ¼ 0.004), tendency to higher triglycerides (P ¼ 0.883) and slight improvement in glycaemia (P ¼ 0.052). Lep values increased significantly during follow-up (P ¼ 0.001) while AdipoQ levels diminished slightly (P ¼ 0.317). Neither Lep nor AdipoQ values showed important correlation (r > 0.5) with metabolic variables or joint swelling. This study suggests that in patients with gout, concentrations of Lep and Adipo Q are more in line with the metabolic state than with clinical disease activity. (Medicine 94(26):e935) Abbreviations: AdipoQ = adiponectin, ATP III = Adult Treatment Panel III, CRF = chronic renal failure, CRP = C reactive protein, DM2 = type 2 diabetes mellitus, GFR = glomerular filtration rate, HDL-C = high density lipoprotein-cholesterol, Lep = leptin, MBP = mean arterial pressure, MDRD = modification of diet in renal disease, MetS = metabolic syndrome, NSAID = non-steroidal anti-inflammatory drugs, OA = osteoarthritis, PPARg = peroxisome proliferator-activated receptors gamma, RA = rheumatoid arthritis, sUA = serum uric acid, TNFa = tumor necrosis factor a, ULD = urate lowering drug.