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American Chemical Society, Organic Letters, 23(11), p. 5422-5424, 2009

DOI: 10.1021/ol901997k

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Lodopyridone, a Structurally Unprecedented Alkaloid from a Marine Actinomycete

Journal article published in 2009 by Katherine N. Maloney, John B. MacMillan, Christopher A. Kauffman, Paul R. Jensen, Antonio G. DiPasquale, Arnold L. Rheingold ORCID, William Fenical ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Chemical examination of the secondary metabolites of a marine Saccharomonospora sp., isolated from marine sediments collected at the mouth of the La Jolla Submarine Canyon, yielded the unprecedented alkaloid lodopyridone (1). The low proton-to-carbon ratio of 1 precluded structure elucidation by NMR spectroscopic methods, thus the structure was defined by X-ray crystallography. Lodopyridone is cytotoxic to HCT-116 human colon cancer cells with IC(50) = 3.6 microM.