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Centers for Disease Control and Prevention, Emerging Infectious Diseases, 9(15), p. 1377-1384

DOI: 10.3201/eid1509.090224

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Distant Relatives of Severe Acute Respiratory Syndrome Coronavirus and Close Relatives of Human Coronavirus 229E in Bats, Ghana

Journal article published in 2009 by Susanne Pfefferle, Samuel Oppong, Jan Felix Drexler ORCID, Florian Gloza-Rausch, Anne Ipsen, Antje Seebens, Marcel A. Müller, Augustina Annan ORCID, Peter Vallo, Yaw Adu-Sarkodie, Thomas F. Kruppa, Christian Drosten
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We tested 12 bat species in Ghana for coronavirus (CoV) RNA. The virus prevalence in insectivorous bats (n = 123) was 9.76%. CoV was not detected in 212 fecal samples from Eidolon helvum fruit bats. Leaf-nosed bats pertaining to Hipposideros ruber by morphology had group 1 and group 2 CoVs. Virus concentrations were < or =45,000 copies/100 mg of bat feces. The diversified group 1 CoV shared a common ancestor with the human common cold virus hCoV-229E but not with hCoV-NL63, disputing hypotheses of common human descent. The most recent common ancestor of hCoV-229E and GhanaBt-CoVGrp1 existed in approximately 1686-1800 ad. The GhanaBt-CoVGrp2 shared an old ancestor (approximately 2,400 years) with the severe acute respiratory syndrome-like group of CoV.