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American Society for Microbiology, Journal of Virology, 1(86), p. 630-634, 2012

DOI: 10.1128/jvi.06120-11

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Generation of HIV Latency in Humanized BLT Mice

Journal article published in 2011 by Paul W. Denton, Rikke Olesen, Shailesh K. Choudhary, Nancy M. Archin, Angela Wahl, Michael D. Swanson, Morgan Chateau, Tomonori Nochi, John F. Krisko, Rae Ann Spagnuolo, David M. Margolis ORCID, J. Victor Garcia, J. Victor Garcia
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Here we demonstrate that a combination of tenofovir, emtricitabine, and raltegravir effectively suppresses peripheral and systemic HIV replication in humanized BLT mice. We also demonstrate that antiretroviral therapy (ART)-treated humanized BLT mice harbor latently infected resting human CD4 + T cells that can be induced ex vivo to produce HIV. We observed that the levels of infected resting human CD4 + T cells present in BLT mice are within the range of those observed circulating in patients undergoing suppressive ART. These results demonstrate the potential of humanized BLT mice as an attractive model for testing the in vivo efficacy of novel HIV eradication strategies.