Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 5(63), 2019
DOI: 10.1128/aac.02612-18
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Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin
Journal article published in 2019 by
Aoife M. Rodgers,
Maelíosa T. C. McCrudden,
Aaron J. Courtenay 
,
Mary-Carmel Kearney,
Katherine L. Edwards,
Rebecca J. Ingram,
Jose Bengoechea,
Ryan F. Donnelly
,
Mary-Carmel Kearney,
Katherine L. Edwards,
Rebecca J. Ingram,
Jose Bengoechea,
Ryan F. Donnelly
This paper is made freely available by the publisher.
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Abstract
Using a murine model of Klebsiella pneumoniae bacterial infection, we demonstrate that gentamicin dissolving microarray patches, applied to murine ears, could control K. pneumoniae infection. Mice treated with microarray patches had reduced bacterial burden in the nasal-associated lymphoid tissue and lungs compared with their untreated counterparts.