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Royal Society of Chemistry, Chemical Science, 16(10), p. 4515-4522, 2019

DOI: 10.1039/c9sc00125e

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Azabicyclic vinyl sulfones for residue-specific dual protein labelling

Journal article published in 2019 by Enrique Gil de Montes, Enrique Gil de Montes, Ester Jiménez-Moreno ORCID, Bruno L. Oliveira, Claudio D. Navo ORCID, Pedro M. S. D. Cal, Gonzalo Jiménez-Osés ORCID, Inmaculada Robina ORCID, Antonio J. Moreno-Vargas ORCID, Gonçalo J. L. Bernardes ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We have developed [2.2.1]azabicyclic vinyl sulfone reagents that simultaneously enable cysteine-selective protein modification and introduce a handle for further bioorthogonal ligation.