Published in
Elsevier, Cell, 2(147), p. 306-319, 2011
DOI: 10.1016/j.cell.2011.08.046
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- ORCID
- Elsevier
- [www.ncbi.nlm.nih.gov] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis
Journal article published in 2011 by
Florian Grebien 
,
Oliver Hantschel,
John Wojcik,
Ines Kaupe,
Boris Kovacic,
Arkadiusz M. Wyrzucki,
Gerald D. Gish,
Sabine Cerny-Reiterer,
Akiko Koide,
Hartmut Beug,
Tony Pawson,
Peter Valent,
Shohei Koide,
Giulio Superti-Furga
,
Oliver Hantschel,
John Wojcik,
Ines Kaupe,
Boris Kovacic,
Arkadiusz M. Wyrzucki,
Gerald D. Gish,
Sabine Cerny-Reiterer,
Akiko Koide,
Hartmut Beug,
Tony Pawson,
Peter Valent,
Shohei Koide,
Giulio Superti-Furga
This paper is available in a repository.
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Abstract
Intramolecular interaction between two domains of Bcr-Abl is essential for its oncogenic activity. Disrupting the interaction prevents leukemia, even in cases where Bcr-Abl has become resistant to existing kinase inhibitors.