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Microbiology Society, Journal of General Virology, 3(90), p. 702-709, 2009

DOI: 10.1099/vir.0.007377-0

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Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5α proteins including human TRIM5α

Journal article published in 2009 by Andrew Wood, Benjamin L. J. Webb, Birke Bartosch, Torsten Schaller ORCID, Yasuhiro Takeuchi, Greg J. Towers ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The potential risk of cross-species transmission of porcine endogenous retroviruses (PERV) to humans has slowed the development of xenotransplantation, using pigs as organ donors. Here, we show that PERVs are insensitive to restriction by divergent TRIM5{alpha} molecules despite the fact that they strongly restrict a variety of divergent lentiviruses. We also show that the human PERV A/C recombinant clone 14/220 reverse transcribes with increased efficiency in human cells, leading to significantly higher infectivity. We conclude that xenotransplantation studies should consider the danger of highly infectious TRIM5{alpha}-insensitive human-tropic PERV recombinants.