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Microbiology Society, Journal of General Virology, 1(90), p. 69-73, 2009

DOI: 10.1099/vir.0.006353-0

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Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments

Journal article published in 2009 by Nigel D. Stow, Vanessa C. Evans, David A. Matthews ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Previous reports have shown that adenovirus recruits nucleolar protein upstream-binding factor (UBF) into adenovirus DNA replication centres. Here, we report that despite having a different mode of viral DNA replication, herpes simplex virus type 1 (HSV-1) also recruits UBF into viral DNA replication centres. Moreover, as with adenovirus, enhanced green fluorescent protein-tagged fusion proteins of UBF inhibit viral DNA replication. We propose that UBF is recruited to the replication compartments to aid replication of HSV-1 DNA. In addition, this is a further example of the role of nucleolar components in viral life cycles.