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Public Library of Science, PLoS ONE, 3(6), p. e17442, 2011

DOI: 10.1371/journal.pone.0017442

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Genes and Gene Ontologies Common to Airflow Obstruction and Emphysema in the Lungs of Patients with COPD

Journal article published in 2011 by Santiyagu M. Savarimuthu Francis, Jill E. Larsen, Sandra J. Pavey, Edwina E. Duhig, Belinda E. Clarke, Rayleen V. Bowman, Nick K. Hayward, Kwun M. Fong, Ian A. Yang ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Chronic obstructive pulmonary disease (COPD) is a major public health problem with increasing prevalence worldwide. The primary aim of this study was to identify genes and gene ontologies associated with COPD severity. Gene expression profiling was performed on total RNA extracted from lung tissue of 18 former smokers with COPD. Class comparison analysis on mild (n = 9, FEV1 80–110% predicted) and moderate (n = 9, FEV1 50–60% predicted) COPD patients identified 46 differentially expressed genes (p