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Nature Research, Nature Reviews Immunology, 3(11), p. 176-186, 2011

DOI: 10.1038/nri2935

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DCs and NK cells: critical effectors in the immune response to HIV-1

Journal article published in 2011 by Marcus Altfeld, Lena Fadda, Davor Frleta, Nina Bhardwaj ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Dendritic cells (DCs) and natural killer (NK) cells have central roles in antiviral immunity by shaping the quality of the adaptive immune response to viruses and by mediating direct antiviral activity. HIV-1 infection is characterized by a severe dysregulation of the antiviral immune response that starts during early infection. This Review describes recent insights into how HIV-1 infection affects DC and NK cell function, and the roles of these innate immune cells in HIV-1 pathogenesis. The importance of understanding DC and NK cell crosstalk during HIV infection for the developement of effective antiviral strategies is also discussed.