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SAGE Publications, Natural Product Communications, 10(10), p. 1934578X1501001, 2015

DOI: 10.1177/1934578x1501001015

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(+)-Chenabinol (Revised NMR Data) and Two New Alkaloids from Berberis vulgaris and their Biological Activity

Journal article published in 2015 by Zdeněk Novák, Anna Hošt'álková, Lubomir Opletal ORCID, Lucie Nováková, Martina Hrabinová, Jiři Kuneš, Lucie Cahliková ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A known alkaloid (+)-chenabinol (1) and two new secobisbenzylisoquinoline alkaloids were isolated by standard chromatographic methods from the root bark of Berberis vulgaris L. The structures of the new alkaloids, named berkristine (2) and verfilline (3), were established by spectroscopic (including 2D NMR), and HRMS (ESI) methods. The alkaloids were tested for their inhibition activity of human cholinesterases and prolyl oligopeptidase. Compound 1 inhibited human butyrylcholinesterase with an IC50 value of 44.8 ± 5.4 μM.