Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 4(63), 2019
DOI: 10.1128/aac.02061-18
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Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection
Journal article published in 2019 by
Frederick S. Buckner 
,
Ranae M. Ranade,
J. Robert Gillespie,
Sayaka Shibata,
Matthew A. Hulverson,
Zhongsheng Zhang,
Wenlin Huang,
Ryan Choi,
Christophe L. M. J. Verlinde,
Wim G. J. Hol,
Atsuko Ochida,
Yuichiro Akao,
Robert K. M. Choy,
Wesley C. Van Voorhis,
Sam L. M. Arnold
and other authors.
,
Ranae M. Ranade,
J. Robert Gillespie,
Sayaka Shibata,
Matthew A. Hulverson,
Zhongsheng Zhang,
Wenlin Huang,
Ryan Choi,
Christophe L. M. J. Verlinde,
Wim G. J. Hol,
Atsuko Ochida,
Yuichiro Akao,
Robert K. M. Choy,
Wesley C. Van Voorhis,
Sam L. M. Arnold
and other authors.
This paper is made freely available by the publisher.
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Abstract
Cryptosporidiosis is one of the leading causes of moderate to severe diarrhea in children in low-resource settings. The therapeutic options for cryptosporidiosis are limited to one drug, nitazoxanide, which unfortunately has poor activity in the most needy populations of malnourished children and HIV-infected persons.