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Elsevier, Journal of Nutritional Biochemistry, 3(21), p. 171-179

DOI: 10.1016/j.jnutbio.2009.08.003

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Antiobesity Mechanisms of Action of Conjugated Linoleic Acid

Journal article published in 2009 by Arion Kennedy, Kristina Martinez, Soren Schmidt, Susanne Mandrup ORCID, Kathleen LaPoint, Michael McIntosh
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Conjugated linoleic acid (CLA), a family of fatty acids found in beef, dairy foods and dietary supplements, reduces adiposity in several animal models of obesity and some human studies. However, the isomer-specific antiobesity mechanisms of action of CLA are unclear, and its use in humans is controversial. This review will summarize in vivo and in vitro findings from the literature regarding potential mechanisms by which CLA reduces adiposity, including its impact on (a) energy metabolism, (b) adipogenesis, (c) inflammation, (d) lipid metabolism and (e) apoptosis.