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Springer Nature [academic journals on nature.com], Pediatric Research, 4(74), p. 384-392, 2013

DOI: 10.1038/pr.2013.127

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Abca3 haploinsufficiency is a risk factor for lung injury induced by hyperoxia or mechanical ventilation in a murine model.

Journal article published in 2013 by Susanne Herber-Jonat, Rashmi Mittal, Marceline Huppmann, Markus Hammel, Gerhard Liebisch, Ali Önder Yildirim, Oliver Eickelberg, Gerd Schmitz, Martin Hrabě de Angelis ORCID, Andreas W. Flemmer, Andreas Holzinger
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background:Heterozygous ABCA3 (ATP-binding-cassette sub-family A member3) mutations are associated with neonatal respiratory complications. We investigated in an adult murine model whether Abca3 haploinsufficiency is a predisposing factor for lung injury induced by hyperoxia or mechanical ventilation.Methods:Abca3 haploinsufficient (Abca3+/-) and wild-type (WT) mice were prospectively randomized to 25 min of ventilation or 72 hours of hyperoxia or left unchallenged in air.Results:As compared to WT, unchallenged Abca3+/- mice had significantly decreased lung phosphatidylcholine (PC) and phosphatidylglycerol (PG) levels (p