The data contained in this article are strictly related to our previous article titled “A Targeted Management of the Nutrient Solution in a Soilless Tomato Crop According to Plant Needs” (Signore, A. et al. 2016). The detailed datasets regards the amount of dry matter (Table 1), the nutrient solution consumption (Table 2) and the mineral composition of plant tissues (Tables 3–7) in a soil-less tomato crop. The information contained in this article are necessary since, unlike the northern European countries, such data are generally missing for the crops in the Mediterranean environment. By correlating the parameters reported above, we were able to provide a more precise management of the nutrient solution, by providing the correct nutrient concentration into the nutrient solution in function of (i) the volume of water absorbed, (ii) the growth rate and (iii) the nutrient concentration in tomato plant. Finally, the more precise management of the nutrient solution allowed discharging a lesser amount of water and nutrients into the environment, improving the sustainability of the crop.