Published in

Rockefeller University Press, Journal of Experimental Medicine, 11(211), p. 2169-2181, 2014

DOI: 10.1084/jem.20140425

Links

Tools

Export citation

Search in Google Scholar

The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation

Journal article published in 2014 by Sebastian Carotta, Simon N. Willis, Jhagvaral Hasbold, Michael Inouye, Swee Heng Milon Pang ORCID, Dianne Emslie, Amanda Light, Michael Chopin, Wei Shi, Hongsheng Wang, Herbert C. Morse, David M. Tarlinton, Lynn M. Corcoran, Philip D. Hodgkin, Stephen L. Nutt ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Red circle
Postprint: archiving forbidden
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Activated B cells undergo immunoglobulin class-switch recombination (CSR) and differentiate into antibody-secreting plasma cells. The distinct transcriptomes of B cells and plasma cells are maintained by the antagonistic influences of two groups of transcription factors: those that maintain the B cell program, including BCL6 and PAX5, and plasma cell–promoting factors, such as IRF4 and BLIMP-1. We show that the complex of IRF8 and PU.1 controls the propensity of B cells to undergo CSR and plasma cell differentiation by concurrently promoting the expression of BCL6 and PAX5 and repressing AID and BLIMP-1. As the PU.1–IRF8 complex functions in a reciprocal manner to IRF4, we propose that concentration-dependent competition between these factors controls B cell terminal differentiation.