Published in
American Society for Microbiology, Journal of Bacteriology, 14(194), p. 3756-3757, 2012
DOI: 10.1128/jb.00692-12
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- ORCID
- American Society for Microbiology | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [repository.edgehill.ac.uk] | PDF
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Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)
Journal article published in 2012 by
Carlos Barreiro,
Carlos Prieto,
Alberto Sola-Landa,
Elena Solera,
Miriam Martínez-Castro,
R. Perez-Redondo,
Rosario Pérez-Redondo,
Carlos García-Estrada 
,
Jesús F. Aparicio,
Lorena T. Fernández-Martínez,
Javier Santos-Aberturas,
Zahra Salehi-Najafabadi,
Antonio Rodríguez-García,
Andreas Tauch,
Juan F. Martín
,
Jesús F. Aparicio,
Lorena T. Fernández-Martínez,
Javier Santos-Aberturas,
Zahra Salehi-Najafabadi,
Antonio Rodríguez-García,
Andreas Tauch,
Juan F. Martín
This paper is made freely available by the publisher.
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Abstract
ABSTRACT The macrocyclic polyketide tacrolimus (FK506) is a potent immunosuppressant that prevents T-cell proliferation produced solely by Streptomyces species. We report here the first draft genome sequence of a true FK506 producer, Streptomyces tsukubaensis NRRL 18488, the first tacrolimus-producing strain that was isolated and that contains the full tacrolimus biosynthesis gene cluster.