Published in
American Society for Microbiology, Infection and Immunity, 3(87), 2019
DOI: 10.1128/iai.00822-18
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Characterization of Pyrin Dephosphorylation and Inflammasome Activation in Macrophages as Triggered by the Yersinia Effectors YopE and YopT
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Abstract
Pathogenic Yersinia species deliver Yop effector proteins through a type III secretion system into host cells. Among these effectors, YopE and YopT are Rho-modifying toxins, which function to modulate host cell physiology and evade immune responses.